The Testis-Enriched Histone Demethylase, KDM4D, Regulates Methylation of Histone H3 Lysine 9 During Spermatogenesis in the Mouse but Is Dispensable for Fertility1
نویسندگان
چکیده
منابع مشابه
Methylation of histone H3 lysine 9 occurs during translation
Histone post-translational modifications are key contributors to chromatin structure and function, and participate in the maintenance of genome stability. Understanding the establishment and maintenance of these marks, along with their misregulation in pathologies is thus a major focus in the field. While we have learned a great deal about the enzymes regulating histone modifications on nucleos...
متن کاملHistone H3 lysine 9 methylation: A signature for chromatin funciton
In most eukaryotes, the histone methyltransferase SU(VAR)3-9 and its orthologues play amajor role in the function of centromeric heterochromatin. Although the methyltransferase domain isrequired for the formation of a fully functional centromere, mutations within other regions of the genesuch as the N-terminus also have a strong impact on its in vivo function. To analyze the contrib...
متن کاملCadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity.
Cadmium is an established human lung carcinogen with weak mutagenicity. However, the mechanisms underlying cadmium-induced carcinogenesis remain obscure. It has been suggested that epigenetic mechanisms may play a role in cadmium-induced carcinogenesis. In this study, we investigated the effects of cadmium on histone methylation and histone demethylases, and the role of histone methylation in t...
متن کاملHistone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases.
This study investigates the mechanism by which histone deacetylase (HDAC) inhibitors up-regulate histone H3 lysine 4 (H3K4) methylation. Exposure of LNCaP prostate cancer cells and the prostate tissue of transgenic adenocarcinoma of the mouse prostate mice to the pan- and class I HDAC inhibitors (S)-(+)-N-hydroxy-4-(3-methyl-2-phenyl-butyrylamino)-benzamide (AR42), N-(2-aminophenyl)-4-[N-(pyrid...
متن کاملSir2 Regulates Histone H3 Lysine 9 Methylation and Heterochromatin Assembly in Fission Yeast
Hypoacetylated histones are a hallmark of heterochromatin in organisms ranging from yeast to humans. Histone deacetylation is carried out by both NAD(+)-dependent and NAD(+)-independent enzymes. In the budding yeast Saccharomyces cerevisiae, deacetylation of histones in heterochromatic chromosomal domains requires Sir2, a phylogenetically conserved NAD(+)-dependent deacetylase. In the fission y...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2011
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.110.088955